Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial

Author(s):

Lennie Derde, Anthony C. Gordon, Paul R. Mouncey, Farah Al-Beidh, Kathryn M. Rowan, Alistair D. Nichol, Yaseen M. Arabi, Djillali Annane, Abigail Beane, Richard Beasley, Marc J.M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Adrian Buzgau, Meredith Buxton, Allen C. Cheng, Nicola Cooper, Matthew Cove, Olaf L. Cremer, Michelle A. Detry, Eamon J. Duffy, Lise J. Estcourt, Mark Fitzgerald, James Galea, Herman Goossens, Rashan Haniffa, Thomas E. Hills, David T. Huang, Nao Ichihara, Andrew King, François Lamontagne, Patrick R. Lawler, Helen L. Leavis, Roger J. Lewis, Edward Litton, John C. Marshall, Florian B. Mayr, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Susan C. Morpeth, Srinivas Murthy, Mihai G. Netea, Kayode Ogungbenro, Katrina Orr, Rachael L. Parke, Jane C. Parker, Asad E. Patanwala, Ville Pettila, Luis Felipe Reyes, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Wendy I. Sligl, Alexis F. Turgeon, Anne M. Turner, Steven Y.C. Tong, Suvi Vaara, Taryn Youngstein, Ryan Zarychanski, Cameron Green, Alisa M. Higgins, Colin J. McArthur, Lindsay R. Berry, Elizabeth Lorenzi, Scott Berry, Steve A. Webb, Derek C. Angus, Frank L. van de Veerdonk

Details:

Thorax, Volume 80, Issue 8, 2025-08-01

Article Link: Click here

Affiliations:

• University of Toronto
• The University of Tokyo
• University of Oxford
• Imperial College London
• The University of British Columbia
• The University of Manchester
• National University of Singapore
• University of Alberta
• Monash University
• University of Pittsburgh
• Helsingin Yliopisto
• University of Bristol
• The University of Western Australia
• The University of Auckland
• Université Laval
• University of Manitoba
• Queen's University Belfast
• Radboud University Medical Center
• University Medical Center Utrecht
• University College Dublin
• Universiteit Antwerpen
• University of Pittsburgh Medical Center
• Université de Sherbrooke
• Université de Versailles Saint-Quentin-en-Yvelines
• Imperial College Faculty of Medicine
• Royal Prince Alfred Hospital
• Nuffield Department of Medicine
• Universitätsklinikum Jena und Medizinische Fakultät
• The Alfred
• McGill Faculty of Medicine and Health Sciences
• St. Marianna University School of Medicine
• King Saud bin Abdulaziz University for Health Sciences
• Auckland City Hospital
• The Peter Doherty Institute for Infection and Immunity
• NHS Blood and Transplant
• Universidad de La Sabana
• Fiona Stanley Hospital
• Unity Health Toronto
• Mahidol Oxford Tropical Medicine Research Unit
• MRC Centre for Inflammation Research
• Middlemore Hospital, Auckland
• Intensive Care National Audit & Research Centre
• Berry Consultants
• Medical Research Institute
• Global Coalition for Adaptive Research