HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes

Author(s):

Louise C. Rowntree, Lilith F. Allen, Ruth R. Hagen, Hayley A. McQuilten, Ahmed A. Quadeer, Priyanka Chaurasia, Prathanporn Kaewpreedee, Kelly W.K. Lee, Carolyn A. Cohen, Jan Petersen, Dene R. Littler, Jennifer R. Habel, Wuji Zhang, Samuel M.S. Cheng, Ken Ka Pang Chan, Janette S.Y. Kwok, Kathy S.M. Leung, Joseph T. Wu, Cheuk Kwong Lee, Jane Davies, Pia S. Pannaraj, E. Kaity Allen, Paul G. Thomas, Shidan Tosif, Nigel W. Crawford, Martha Lappas, Irani Thevarajan, Sharon R. Lewin, Stephen J. Kent, Jennifer A. Juno, Katherine A. Bond, Deborah A. Williamson, Natasha E. Holmes, Olivia C. Smibert, Claire L. Gordon, Jason A. Trubiano, Tom C. Kotsimbos, Allen C. Cheng, Claudia Efstathiou, Lance Turtle, Ryan S. Thwaites, Christopher E. Brightling, Jamie Rossjohn, Matthew R. McKay, Jinmin Tian, William Jun Liu, George Fu Gao, Jianqing Xu, Kyuto Sonehara, Ken J. Ishii, Ho Namkoong, Yukinori Okada, Malik Peiris, David S.C. Hui, Leo L.M. Poon, Peter C. Doherty, Thi H.O. Nguyen, Sophie A. Valkenburg, Katherine Kedzierska

Details:

Proceedings of the National Academy of Sciences of the United States of America, Volume 122, Issue 36, 2025-01-01, Article number e2503145122

Article Link: Click here

Affiliations:

• University of California, Los Angeles
• University of Melbourne
• Monash University
• The University of Osaka
• Fudan University
• University of Liverpool
• Hokkaido University
• Chinese University of Hong Kong
• Hong Kong University of Science and Technology
• University of Leicester
• Graduate School of Medicine
• Royal Melbourne Hospital
• Graduate School of Medicine
• St. Jude Children's Research Hospital
• Chinese Center for Disease Control and Prevention
• Keio University School of Medicine
• Royal Children's Hospital, Melbourne
• National Heart and Lung Institute
• Murdoch Children's Research Institute
• Children's Hospital Los Angeles
• Queen Mary Hospital Hong Kong
• The Alfred
• Peter Maccallum Cancer Centre
• The University of Hong Kong Li Ka Shing Faculty of Medicine
• Austin Health
• Chinese University of Hong Kong, Faculty of Medicine
• Cardiff University School of Medicine
• Menzies School of Health Research
• The Peter Doherty Institute for Infection and Immunity
• RIKEN Center for Integrative Medical Sciences
• The Institute of Medical Science, The University of Tokyo
• WPI Immunology Frontier Research Center, The University of Osaka
• The University of Hong Kong-Shenzhen Hospital
• School of Medicine
• National Institutes of Biomedical Innovation, Health and Nutrition
• Department of Electrical and Electronic Engineering
• Laboratory of Data Discovery for Health
• HKU-Pasteur Research Pole
• New Territories
• The Hong Kong Jockey Club Global Health Institute