High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

Author(s):

Aira F. Cabug, Jeremy Chase Crawford, Hayley A. McQuilten, Isabelle J.H. Foo, Lilith F. Allen, Deborah Gebregzabher, Robert C. Mettelman, Tanya Novak, Janet Chou, Louise C. Rowntree, Ruth R. Hagen, Abby J. Thomson, Genevieve E. Martin, Brad Gilbertson, Michael N.T. Souter, Fiona James, Emma Goodall, Simone Rizzetto, Tim Flerlage, Xiaoxiao Jia, Lee Ann Van de Velde, So Young Chang, Fabio Luciani, Ryan S. Thwaites, Jason A. Trubiano, Tom C. Kotsimbos, Allen C. Cheng, Adrienne G. Randolph, Paul G. Thomas, Jianqing Xu, Zhongfang Wang, Thi H.O. Nguyen, Brendon Y. Chua, Lukasz Kedzierski, Katherine Kedzierska

Details:

Nature Communications, Volume 16, Issue 1, 2025-12-01, Article number 10344

Article Link: Click here

Affiliations:

• Harvard Medical School
• Monash University
• Fudan University
• University of Tennessee Health Science Center
• St. Jude Children's Research Hospital
• UNSW Medicine
• National Heart and Lung Institute
• Department of Medicine
• The Alfred
• Peter Maccallum Cancer Centre
• Austin Health
• The First Affiliated Hospital of Guangzhou Medical University
• Department of Microbiology & Immunology
• Center for Influenza Disease and Emergence Response (CIDER)