Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum

Author(s):

Rebecca Webster, Damian A. Oyong, Stacey Llewellyn, Azrin N. Abd-Rahman, Adam J. Potter, Reena Mukhiya, Nischal Sahai, Indika Leelasena, Eniko Ujvary, Sue Mathison, Dean W. Andrew, Luzia Bukali, Fabian de Labastida Rivera, Jessica Engel, Megan S.F. Soon, Teija Frame, Julianne Hamelink, Mayimuna Nalubega, Nicholas L. Dooley, Jessica R. Loughland, Tran Nguyen, Yael Rosenberg-Hasson, Sofia Maysel-Auslender, Natalia Sigal, Kira Foygel, Jeremy Gower, Jenny Peters, Ria Woo, Fiona Amante, Timothy N.C. Wells, Stephan Chalon, Joerg J. Moehrle, James S. McCarthy, Geoffrey W. Birrell, Michael D. Edstein, Michael Leipold, Gerlinde Obermoser, Holden Maecker, Christian R. Engwerda, Bridget E. Barber, Michelle J. Boyle

Details:

Science Translational Medicine, Volume 17, Issue 826, 2025-11-26, Article number eaea2531

Article Link: Click here

Affiliations:

• Stanford University
• The University of Queensland
• Universität Basel
• Griffith University
• Royal Brisbane and Women's Hospital
• QIMR Berghofer Medical Research Institute
• Swiss Tropical and Public Health Institute Swiss TPH
• George Institute for Global Health
• Menzies School of Health Research
• The Peter Doherty Institute for Infection and Immunity
• Burnet Institute
• Medicines for Malaria Venture
• Australian Defence Force Malaria and Infectious Disease Institute
• University of Sunshine Coast Clinical Trials