Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

Author(s):

Ema T. Crooks, Samantha L. Grimley, Michelle Cully, Keiko Osawa, Gillian Dekkers, Kevin Saunders, Sebastian Rämisch, Sergey Menis, William R. Schief, Nicole Doria-Rose, Barton Haynes, Ben Murrell, Evan Mitchel Cale, Amarendra Pegu, John R. Mascola, Gestur Vidarsson, James M. Binley

Details:

PLoS Pathogens, Volume 14, Issue 5, 2018-05-01, Article number e1007024

Article Link: Click here

Affiliations:

• Universiteit van Amsterdam
• Duke University Medical Center
• Scripps Research Institute
• National Institute of Allergy and Infectious Diseases (NIAID)
• Department of Medicine
• Department of Microbiology & Immunology
• San Diego Biomedical Research Institute
• Ragon Institute