Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing

Author(s):

Wenxin Hu, Amit Kumar, Syed Faraz Ahmed, Shijiao Qi, David K.G. Ma, Honglin Chen, Gurjeet J. Singh, Joshua M.L. Casan, Michelle Haber, Ilia Voskoboinik, Matthew R. McKay, Joseph A. Trapani, Paul G. Ekert, Mohamed Fareh

Details:

Nature Structural and Molecular Biology, Volume 31, Issue 11, 2024-11-01

Article Link: Click here

Affiliations:

• University of Melbourne
• The UNSW Lowy Cancer Research Centre
• The Peter Doherty Institute for Infection and Immunity
• Peter Maccallum Cancer Centre
• UNSW Sydney
• Royal Children's Hospital, Melbourne
• Monash Medical Centre