Maternal Tmprss6 is required for hepcidin suppression and fetal health

Authors:

• Fielding, Katherine L.
• Bennett, Cavan
• Pettikiriarachchi, Anne
• Jones, Naomi
• Harding, Rebecca
• McLean, Alistair R. D.
• Randall, Louise
• Schaeper, Ute
• Martinez, Alberto
• Ataíde, Ricardo
• Pasricha, Sant-Rayn

Details:

Blood, Volume 145, Issue 25, 2025-06-19

Article Link: Click here

Abstract The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.