Noncoding RNA gives agency to the molecular and cellular substrates of learning and memory

Authors:

• Walsh, Alexander D.
• Bredy, Timothy W.

Details:

Current Opinion in Neurobiology, Volume 93, 2025-08-31

Article Link: Click here

In the past decade, there has been a virtual explosion in the appreciation and study of noncoding RNA (ncRNA) in the brain. Rapidly emerging evidence suggests that many classes of ncRNA coordinate processes related to learning and memory, achieved via their precise subcellular localisation and interactions with DNA, mRNA and RNA binding proteins. Here we discuss these mechanisms using examples of recently discovered and well-studied ncRNAs, including long noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs), which are directly involved in regulating experience-dependent neural plasticity.