Antibody-dependent cellular cytotoxicity and influenza virus

Authors:

• Vanderven, Hillary A
• Jegaskanda, Sinthujan
• Wheatley, Adam K
• Kent, Stephen J

Details:

Current Opinion in Virology, Volume 22, 2017-02-28

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Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza-specific ADCC antibodies.