Transcription Factor Theft—PU.1 Caught Red-Handed

Authors:

• Kallies, Axel
• Nutt, Stephen L.

Details:

Immunity, Volume 48, Issue 6, 2018-06-19

Article Link: Click here

The mechanistic understanding of gene-expression regulation is still evolving. In this issue of Immunity, Hosokawa et al. (2018) reveal that PU.1 represses transcription indirectly during early T cell development by “stealing” other regulators such as Runx1 and Satb1 from their DNA binding sites.