Typhoid Fever: The More We Learn, the Less We Know (Apologies, Albert Einstein)

Authors:

• Wang, Nancy
• Knodler, Leigh A.
• Strugnell, Richard A.

Details:

Cell Host & Microbe, Volume 26, Issue 3, 2019-09-11

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In this issue of Cell Host & Microbe, Karlinsey et al. (2019) combine TraDIS with humanized mice to identify genes required for early replication of Salmonella Typhi in vivo. Surprisingly, some expected virulence traits and genes appear dispensable in the replication of S. Typhi, supporting findings from a recent human challenge study by Gibani et al. (2019).