Bhlhe40 Keeps Resident T Cells Too Fit to Quit

Authors:

• Park, Simone L.
• Mackay, Laura K.

Details:

Immunity, Volume 51, Issue 3, 2019-09-17

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Factors regulating the differentiation of tissue-resident memory T (TRM) cells and tumor-infiltrating lymphocytes (TILs) are incompletely understood. In this issue of Immunity, Li et al. identify Bhlhe40 as a transcriptional regulator of CD8+ TRM cell and TIL persistence and activity by orchestrating metabolic and epigenetic programming.