Immune imprinting and SARS-CoV-2 vaccine design

Authors:

• Wheatley, Adam K.
• Fox, Annette
• Tan, Hyon-Xhi
• Juno, Jennifer A.
• Davenport, Miles P.
• Subbarao, Kanta
• Kent, Stephen J.

Details:

Trends in Immunology, Volume 42, Issue 11, 2021-11-30

Article Link: Click here

Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines.