Rosettes: a shield for Plasmodium falciparum against artemisinins?

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Trends in Parasitology, Volume 38, Issue 3, 2022-03-31

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Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al . describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance.