IRF2 integrates inflammatory signals to balance T cell exhaustion

Authors:

• Sheikh, Amania A.
• Utzschneider, Daniel T.

Details:

Immunity, Volume 55, Issue 12, 2022-12-13

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The transcription factor interferon regulatory factor 2 (IRF2) translates interferon signaling to regulate T cells. In this issue of Immunity, Lukhele et al. identify IRF2 in tumor-infiltrating T cells as a sensor for extrinsic signals that drives an exhaustion program.