Functional flexibility and plasticity in immune control of systemic Salmonella infection

Authors:

• Engel, Sven
• Bachem, Annabell
• Strugnell, Richard A
• Strasser, Andreas
• Herold, Marco J
• Bedoui, Sammy

Details:

Current Opinion in Immunology, Volume 83, 2023-08-31

Article Link: Click here

Immunity to systemic Salmonella infection depends on multiple effector mechanisms. Lymphocyte-derived interferon gamma (IFN-γ) enhances cell-intrinsic bactericidal capabilities to antagonize the hijacking of phagocytes as replicative niches for Salmonella. Programmed cell death (PCD) provides another means through which phagocytes fight against intracellular Salmonella. We describe remarkable levels of flexibility with which the host coordinates and adapts these responses. This involves interchangeable cellular sources of IFN-γ regulated by innate and adaptive cues, and the rewiring of PCD pathways in previously unknown ways. We discuss that such plasticity is likely the consequence of host–pathogen coevolution and raise the possibility of further functional overlap between these seemingly distinct processes.