Laboratory diagnosis of HIV: a contemporary overview in the Australian context

Authors:

• Williams, Eloise
• Moso, Michael
• Lim, Chuan
• Chibo, Doris
• Nicholson, Suellen
• Jackson, Kathy
• Williamson, Deborah Anne

Details:

Pathology, Volume 55, Issue 5, 2023-08-31

Article Link: Click here

Over the past decade there have been technical advances in human immunodeficiency virus (HIV) assays and updates to testing regulations that have substantially changed the landscape of laboratory testing for HIV. In addition, there have been significant changes in the epidemiology of HIV in Australia in the context of highly effective contemporary biomedical treatment and prevention strategies. Here, we provide an update on contemporary issues for the laboratory detection and confirmation of HIV in Australia. These include (1) the impact of early treatment and biological prevention strategies on the serological and virological detection of HIV; (2) the updated national HIV laboratory case definition and its interaction with testing regulations, public health and clinical guidelines; and (3) novel strategies for the laboratory detection of HIV, including the incorporation of HIV nucleic acid amplification tests (NAATs) into testing algorithms. These developments present an opportunity to develop a nationally consistent contemporary HIV testing algorithm that would result in optimisation and standardisation of HIV testing in Australia.