Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis

Authors:

• Saeed, Maria
• Aitken, Elizabeth H.
• Rogerson, Stephen J.

Details:

Trends in Parasitology, Volume 40, Issue 4, 2024-04-30

Article Link: Click here

Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.