Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines—an exploratory sub-study of the BRACE trial

Authors:

• Messina, Nicole L.
• Germano, Susie
• McElroy, Rebecca
• Bonnici, Rhian
• Grubor-Bauk, Branka
• Lynn, David J.
• McDonald, Ellie
• Nicholson, Suellen
• Perrett, Kirsten P.
• Pittet, Laure F.
• Rudraraju, Rajeev
• Stevens, Natalie E.
• Subbarao, Kanta
• Curtis, Nigel
• Curtis, Nigel
• Davidson, Andrew
• Gardiner, Kaya
• Gwee, Amanda
• Jamieson, Tenaya
• Messina, Nicole
• Morawakage, Thilanka
• Perlen, Susan
• Perrett, Kirsten
• Pittet, Laure
• Sastry, Amber
• Teo, Jia Wei
• Orsini, Francesca
• Lee, Katherine
• Moore, Cecilia
• Vidmar, Suzanna
• Pittet, Laure
• Ali, Rashida
• Dunn, Ross
• Edler, Peta
• Gell, Grace
• Goodall, Casey
• Hall, Richard
• Krastev, Ann
• La, Nathan
• McDonald, Ellie
• McPhate, Nick
• Nguyen, Thao
• Ren, Jack
• Stevens, Luke
• Messina, Nicole
• Alamrousi, Ahmed
• Bonnici, Rhian
• Dang, Thanh
• Germano, Susie
• Hua, Jenny
• McElroy, Rebecca
• Razmovska, Monica
• Reddiex, Scott
• Wang, Xiaofang
• Anderson, Jeremy
• Azzopardi, Kristy
• Bennett-Wood, Vicki
• Czajko, Anna
• Mazarakis, Nadia
• McCafferty, Conor
• Oppedisano, Frances
• Ortika, Belinda
• Pell, Casey
• Spry, Leena
• Toh, Ryan
• Velagapudi, Sunitha
• Vlahos, Amanda
• Wee-Hee, Ashleigh
• Ramos, Pedro
• De La Cruz, Karina
• Gamage, Dinusha
• Karunanayake, Anushka
• Mezzetti, Isabella
• Ong, Benjamin
• Singh, Ronita
• Sooriyarachchi, Enoshini
• Nicholson, Suellen
• Cain, Natalie
• Brizuela, Rianne
• Huang, Han
• Abruzzo, Veronica
• Bealing, Morgan
• Bimboese, Patricia
• Bowes, Kirsty
• Burrell, Emma
• Chan, Joyce
• Cushnahan, Jac
• Elborough, Hannah
• Elkington, Olivia
• Fahey, Kieran
• Fernandez, Monique
• Flynn, Catherine
• Fowler, Sarah
• Andrit, Marie Gentile
• Gladanac, Bojana
• Hammond, Catherine
• Ma, Norine
• Macalister, Sam
• Milojevic, Emmah
• Mojeed, Jesutofunmi
• Nguyen, Jill
• O’Donnell, Liz
• Olivier, Nadia
• Ooi, Isabelle
• Reynolds, Stephanie
• Shen, Lisa
• Sherry, Barb
• Spotswood, Judith
• Wedderburn, Jamie
• Younes, Angela
• Legge, Donna
• Bell, Jason
• Cheah, Jo
• Cobbledick, Annie
• Lim, Kee
• Elia, Sonja
• Addlem, Lynne
• Bourke, Anna
• Brophy, Clare
• Henare, Nadine
• Jenkins, Narelle
• Machingaifa, Francesca
• Miller, Skye
• Mitchell, Kirsten
• Pitkin, Sigrid
• Wall, Kate
• Villanueva, Paola
• Crawford, Nigel
• Pittet, Laure
• Norton, Wendy
• Tan, Niki
• Chengodu, Thilakavathi
• Dawson, Diane
• Gordon, Victoria
• Korman, Tony
• O’Bryan, Jess
• Abruzzo, Veronica
• Agius, Sophie
• Bannister, Samantha
• Bucholc, Jess
• Burns, Alison
• Camesella, Beatriz
• Carlin, John
• Ciaverella, Marianna
• Curtis, Maxwell
• Firth, Stephanie
• Guo, Christina
• Hannan, Matthew
• Hill, Erin
• Joshi, Sri
• Lieschke, Katherine
• Mathers, Megan
• Odoi, Sasha
• Rak, Ashleigh
• Richards, Chris
• Steve, Leah
• Stewart, Carolyn
• Sudbury, Eva
• Thomson, Helen
• Watts, Emma
• Williams, Fiona
• Young, Angela
• Glenn, Penny
• Kaynes, Andrew
• De Floy, Amandine Philippart
• Buchanan, Sandy
• Sondag, Thijs
• Xie, Ivy
• Edmund, Harriet
• Byrne, Bridie
• Keeble, Tom
• Ngien, Belle
• Noonan, Fran
• Wearing-Smith, Michelle
• Clarke, Alison
• Davies, Pemma
• Eastwood, Oliver
• Ellinghaus, Alric
• Ghieh, Rachid
• Hilton, Zahra
• Jennings, Emma
• Kakkos, Athina
• Liang, Iris
• Nicol, Katie
• O’Callaghan, Sally
• Osman, Helen
• Rajaram, Gowri
• Ratcliffe, Sophia
• Rayner, Victoria
• Salmon, Ashleigh
• Scheppokat, Angela
• Stevens, Aimee
• Street, Rebekah
• Toogood, Nicholas
• Wood, Nicholas
• Bahaduri, Twinkle
• Baulman, Therese
• Byrne, Jennifer
• Carter, Candace
• Corbett, Mary
• Dao, Aiken
• Desylva, Maria
• Dunn, Andrew
• Gardiner, Evangeline
• Joyce, Rosemary
• Kandasamy, Rama
• Munns, Craig
• Pelayo, Lisa
• Sharma, Ketaki
• Sterling, Katrina
• Uren, Caitlin
• Colaco, Clinton
• Douglas, Mark
• Hamilton, Kate
• Bartlett, Adam
• McMullan, Brendan
• Palasanthiran, Pamela
• Williams, Phoebe
• Beardsley, Justin
• Bergant, Nikki
• Lagunday, Renier
• Overton, Kristen
• Post, Jeffrey
• Al-Hindawi, Yasmeen
• Barney, Sarah
• Byrne, Anthony
• Mead, Lee
• Plit, Marshall
• Lynn, David
• Benson, Saoirse
• Blake, Stephen
• Botten, Rochelle
• Chern, Tee Yee
• Eden, Georgina
• Griffith, Liddy
• James, Jane
• Lynn, Miriam
• Markow, Angela
• Sacca, Domenic
• Stevens, Natalie
• Wesselingh, Steve
• Doran, Catriona
• Barry, Simone
• Sawka, Alice
• Evans, Sue
• Goodchild, Louise
• Heath, Christine
• Krieg, Meredith
• Marshall, Helen
• McMillan, Mark
• Walker, Mary
• Richmond, Peter
• Amenyogbe, Nelly
• Anthony, Christina
• Arnold, Annabelle
• Arrowsmith, Beth
• Ben-Othman, Rym
• Clark, Sharon
• Dunnill, Jemma
• Eiffler, Nat
• Ewe, Krist
• Finucane, Carolyn
• Flynn, Lorraine
• Gibson, Camille
• Hartnell, Lucy
• Hollams, Elysia
• Hutton, Heidi
• Jarvis, Lance
• Jones, Jane
• Jones, Jan
• Jones, Karen
• Kent, Jennifer
• Kollmann, Tobias
• Lalich, Debbie
• Lee, Wenna
• Lim, Rachel
• McAlister, Sonia
• McDonald, Fiona
• Meehan, Andrea
• Minhaj, Asma
• Montgomery, Lisa
• O’Donnell, Melissa
• Ong, Jaslyn
• Ong, Joanne
• Parkin, Kimberley
• Perez, Glady
• Power, Catherine
• Rezazadeh, Shadie
• Richmond, Holly
• Rogers, Sally
• Schultz, Nikki
• Shave, Margaret
• Skut, Patrycja
• Stiglmayer, Lisa
• Truelove, Alexandra
• Wadia, Ushma
• Wallace, Rachael
• Waring, Justin
• England, Michelle
• Latkovic, Erin
• Manning, Laurens
• Herrmann, Susan
• Lucas, Michaela
• Lacerda, Marcus
• Andrade, Paulo Henrique
• Barbosa, Fabiane Bianca
• Barros, Dayanne
• Brasil, Larissa
• Capella, Ana Greyce
• Castro, Ramon
• Costa, Erlane
• de Souza, Dilcimar
• Dias, Maianne
• Dias, José
• Ferreira, Klenilson
• Figueiredo, Paula
• Freitas, Thamires
• Furtado, Ana Carolina
• Gama, Larissa
• Godinho, Vanessa
• Gouy, Cintia
• Hinojosa, Daniele
• Jardim, Bruno
• Jardim, Tyane
• Junior, Joel
• Lima, Augustto
• Maia, Bernardo
• Marins, Adriana
• Mazurega, Kelry
• Medeiros, Tercilene
• Melo, Rosangela
• Moraes, Marinete
• Nascimento, Elizandra
• Neves, Juliana
• Oliveira, Maria Gabriela
• Oliveira, Thais
• Oliveira, Ingrid
• Otsuka, Arthur
• Paes, Rayssa
• Pereira, Handerson
• Pereira, Gabrielle
• Prado, Christiane
• Queiroz, Evelyn
• Rodrigues, Laleyska
• Rodrigues, Bebeto
• Sampaio, Vanderson
• Santos, Anna Gabriela
• Santos, Daniel
• Santos, Tilza
• Santos, Evelyn
• Sartim, Ariandra
• Silva, Ana Beatriz
• Silva, Juliana
• Silva, Emanuelle
• Simão, Mariana
• Soares, Caroline
• Sousa, Antonny
• Trindade, Alexandre
• Val, Fernando
• Vasconcelos, Adria
• Vasconcelos, Heline
• Croda, Julio
• Abreu, Carolinne
• Almeida, Katya Martinez
• Bitencourt de Andrade, Camila
• Campos Angelo, Jhenyfer Thalyta
• Gonçalvez de Araújo Arcanjo, Ghislaine
• Silva Menezes Arruda, Bianca Maria
• Ayala, Wellyngthon Espindola
• Refosco Barbosa, Adelita Agripina
• Vieira Batista, Felipe Zampieri
• de Morais Batista, Fabiani
• de Jesus Costa, Miriam
• Croda, Mariana Garcia
• Alves da Cruz, Lais
• Pereira Diogo, Roberta Carolina
• Dutra Escobar, Rodrigo Cezar
• Fernandes, Iara Rodrigues
• Figueiredo, Leticia Ramires
• Cavalcanti Gonçalves, Leandro Galdino
• Lahdo, Sarita
• Lencina, Joyce dos Santos
• Teodoro de Lima, Guilherme
• Matos, Larissa Santos
• Leopoldina Meireles, Bruna Tayara
• Moreira, Debora Quadros
• Silva Muranaka, Lilian Batista
• de Oliveira, Adriely
• Warszawski de Oliveira, Karla Regina
• Vieira de Oliveira, Matheus
• Dias de Oliveira, Roberto
• Souza de Almeida dos Reis Pereira, Andrea Antonia
• Puga, Marco
• Ramos, Caroliny Veron
• Souza da Rosa, Thaynara Haynara
• Lopes dos Santos, Karla
• Ribeiro dos Santos, Claudinalva
• Leopoldina dos Santos, Dyenyffer Stéffany
• Santos, Karina Marques
• Pereira da Silva, Paulo César
• Rocha da Silva, Paulo Victor
• Silva, Débora dos Santos
• Vieira da Silva, Patricia
• Freitas da Rosa Soares, Bruno
• Sperotto, Mariana Gazzoni
• Tadokoro, Mariana Mayumi
• Tsuha, Daniel
• Ramos Vieira, Hugo Miguel
• Pretti Dalcolmo, Margareth Maria
• Lopes Alves da Paixão, Cíntia Maria
• Corrêa E Castro, Gabriela
• Collopy, Simone Silva
• da Costa Silva, Renato
• Almeida da Silveira, Samyra
• Da-Cruz, Alda Maria
• Maria da Silva Passos de Carvalho, Alessandra
• de Cássia Batista, Rita
• Silva De Freitas, Maria Luciana
• Gerhardt de Oliveira Ferreira, Aline
• Conceição de Souza, Ana Paula
• Doblas, Paola Cerbino
• Alcoforado da Silva dos Santos, Ayla
• Cristine de Moraes dos Santos, Vanessa
• Alves dos Santos Gomes, Dayane
• Fortunato, Anderson Lage
• Gomes-Silva, Adriano
• Gonçalves, Monique Pinto
• Garcia Meireless Junior, Paulo Leandro
• Martins da Costa Carvalho, Estela
• Motta, Fernando do Couto
• Olivo de Mendonça, Ligia Maria
• Pandine, Girlene dos Santos
• Plácido Pereira, Rosa Maria
• Maia, Ivan Ramos
• Luiz da Rocha, Jorge
• Paiva Romano, João Victor
• Santos, Glauce dos
• Fernandes da Silva, Erica
• Mendonça Teixeira de Siqueira, Marilda Agudo
• Prudêncio Soares, Ágatha Cristinne
• Bonten, Marc
• Arroyo, Sandra Franch
• Besten, Henny Ophorst-den
• Boon, Anna
• Brakke, Karin M.
• Janssen, Axel
• Koopmans, Marijke A.H.
• Lemmens, Toos
• Leurink, Titia
• Prat-Aymerich, Cristina
• Septer-Bijleveld, Engelien
• Stadhouders, Kimberly
• Troeman, Darren
• van der Waal, Marije
• van Opdorp, Marjoleine
• van Sluis, Nicolette
• Wolters, Beatrijs
• Kluytmans, Jan
• Romme, Jannie
• van den Bijllaardt, Wouter
• van Mook, Linda
• Rijen, M.M.L (Miranda) van
• Filius, Margreet
• Gisolf, Jet
• Greven, Frances
• Huijbens, Danique
• Hassing, Robert Jan
• Pon, Roos
• Preijers, Lieke
• van Leusen, Joke
• Verheij, Harald
• Boersma, Wim
• Brans, Evelien
• Kloeg, Paul
• Molenaar-Groot, Kitty
• Nguyen, Nhat Khanh
• Paternotte, Nienke
• Rol, Anke
• Stooper, Lida
• Dijkstra, Helga
• Eggenhuizen, Esther
• Huijs, Lucas
• Moorlag, Simone
• Netea, Mihai
• Pranger, Eva
• Taks, Esther
• Oever, Jaap ten
• Heine, Rob ter
• Blauwendraat, Kitty
• Meek, Bob
• Erkaya, Isil
• Harbech, Houda
• Roescher, Nienke
• Peeters, Rifka
• Riele, Menno te
• Zhou, Carmen
• Calbo, Esther
• Marti, Cristina Badia
• Palomares, Emma Triviño
• Porcuna, Tomás Perez
• Barriocanal, Anabel
• Barriocanal, Ana Maria
• Casas, Irma
• Dominguez, Jose
• Esteve, Maria
• Lacoma, Alicia
• Latorre, Irene
• Molina, Gemma
• Molina, Barbara
• Rosell, Antoni
• Vidal, Sandra
• Barrera, Lydia
• Bustos, Natalia
• Calderón, Ines Portillo
• Campos, David Gutierrez
• Carretero, Jose Manuel
• Castellano, Angel Dominguez
• Compagnone, Renato
• Ramirez de Arellano, Encarnacion
• Serna, Almudena de la
• Dolores del Toro Lopez, Maria
• Clement Espindola, Marie-Alix
• Martin Gutierrez, Ana Belen
• Hernandez, Alvaro Pascual
• Jiménez, Virginia Palomo
• Moreno, Elisa
• Navarrete, Nicolas
• Paño, Teresa Rodriguez
• Rodríguez-Baño, Jesús
• Tristán, Enriqueta
• Rios Villegas, Maria Jose
• Garces, Atsegiñe Canga
• Amo, Erika Castro
• Guerrero, Raquel Coya
• Goikoetxea, Josune
• Jorge, Leticia
• Perez, Cristina
• Fariñas Álvarez, María Carmen
• Cuadra, Manuel Gutierrez
• Arnaiz de las Revillas Almajano, Francisco
• Garcia, Pilar Bohedo
• Poderos, Teresa Giménez
• Rico, Claudia González
• Sanchez, Blanca
• Valero, Olga
• Vega, Noelia
• Campbell, John
• Barnes, Anna
• Catterick, Helen
• Cranston, Tim
• Dawe, Phoebe
• Fletcher, Emily
• Fouracre, Liam
• Gifford, Alison
• Kirkwood, John
• Martin, Christopher
• McAnew, Amy
• Mitchell, Marcus
• Newman, Georgina
• O’Connell, Abby
• Onysk, Jakob
• Quinn, Lynne
• Rhodes, Shelley
• Stone, Samuel
• Symons, Lorrie
• Tripp, Harry
• Warris, Adilia
• Watkins, Darcy
• Whale, Bethany
• Harding, Alex
• Lockhart, Gemma
• Sidaway-Lee, Kate
• Campbell, John
• Hilton, Sam
• Manton, Sarah
• Webber-Rookes, Daniel
• Winder, Rachel
• Moore, James
• Bateman, Freya
• Gibbons, Michael
• Knight, Bridget
• Moss, Julie
• Statton, Sarah
• Studham, Josephine
• Hall, Lydia
• Moyle, Will
• Venton, Tamsin

Details:

eBioMedicine, Volume 103, 2024-05-31

Article Link: Click here

Background The COVID-19 pandemic led to the rapid development and deployment of several highly effective vaccines against SARS-CoV-2. Recent studies suggest that these vaccines may also have off-target effects on the immune system. We sought to determine and compare the off-target effects of the adenovirus vector ChAdOx1-S (Oxford-AstraZeneca) and modified mRNA BNT162b2 (Pfizer-BioNTech) vaccines on immune responses to unrelated pathogens. Methods Prospective sub-study within the BRACE trial. Blood samples were collected from 284 healthcare workers before and 28 days after ChAdOx1-S or BNT162b2 vaccination. SARS-CoV-2-specific antibodies were measured using ELISA, and whole blood cytokine responses to specific (SARS-CoV-2) and unrelated pathogen stimulation were measured by multiplex bead array. Findings Both vaccines induced robust SARS-CoV-2 specific antibody and cytokine responses. ChAdOx1-S vaccination increased cytokine responses to heat-killed (HK) Candida albicans and HK Staphylococcus aureus and decreased cytokine responses to HK Escherichia coli and BCG. BNT162b2 vaccination decreased cytokine response to HK E. coli and had variable effects on cytokine responses to BCG and resiquimod (R848). After the second vaccine dose, BNT162b2 recipients had greater specific and off-target cytokine responses than ChAdOx1-S recipients. Interpretation ChAdOx1-S and BNT162b2 vaccines alter cytokine responses to unrelated pathogens, indicative of potential off-target effects. The specific and off-target effects of these vaccines differ in their magnitude and breadth. The clinical relevance of these findings is uncertain and needs further study. Funding Bill & Melinda Gates Foundation, National Health and Medical Research Council, Swiss National Science Foundation and the Melbourne Children’s. BRACE trial funding is detailed in acknowledgements.