Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional sub-study protocol

Authors:

• Anpalagan, Keerthi
• Bowen, Asha C.
• Lamborn, Leanne
• Roebuck, Derek
• Carter, Tina
• Cannon, Jeffrey W.
• Symons, Caitlin
• McNally, Jane
• Woods, Gillian
• McMullan, Brendan
• Gwee, Amanda
• Tong, Steven Y.C.
• Davis, Joshua S.
• Campbell, Anita J.

Details:

Infectious Diseases Now, Volume 55, Issue 1, 2025-02-28

Article Link: Click here

Introduction Staphylococcus aureus bacteraemia (SAB) is the most common cause of sepsis, contributing to paediatric intensive care unit admission in Australia and New Zealand. While deep venous thrombosis (DVT) has been reported in children with invasive S. aureus infections, the actual frequency and possible effects of thrombosis on disease severity and outcome in paediatric SAB remain unknown. Moreover, guidance regarding imaging for paediatric SAB management are poorly defined. Methods and analysis We report the protocol for the SNOOPY (Staphylococcus aureus Network; ultrasOund for diagnOsis of endovascular disease in Paediatrics and Youth) study. SNOOPY is a pilot prospective single-arm interventional study that aims to investigate the proportion of children with SAB that have venous thrombosis detected using whole body doppler ultrasound.