Malaria monoclonals block brain binding

Authors:

• Rogerson, Stephen J.
• Walker, Isobel S.
• Aitken, Elizabeth H.

Details:

Trends in Parasitology, 2025-01-03

Article Link: Click here

In Plasmodium falciparum malaria, infected cells accumulate in blood vessels of organs, including the brain. Recently, Reyes et al . identified monoclonal antibodies that stop infected cells from binding to the endothelial protein C receptor (EPCR) in a model of brain blood vessels. EPCR-blocking monoclonals could form the basis of new treatments for severe malaria.