IgG sialylation puts lung inflammation to REST

Authors:

• Kedzierski, Lukasz
• Kedzierska, Katherine

Details:

Immunity, Volume 58, Issue 1, 2025-01-14

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The mechanisms underpinning susceptibility to influenza virus infection, resulting in life-threatening disease, are not well understood. In this issue of Immunity, Chakraborty et al. demonstrate that sialylated IgG suppresses NF-κB-driven inflammatory responses in the lungs by inducing repressor element-1 silencing transcription factor (REST) to prevent excessive inflammation without impacting viral replication.