Project: Immuno-paralysis following severe infections or trauma
Villadangos Group
Systemic Inflammatory Response Syndrome (SIRS) is a common condition associated with severe infections and trauma. It is characterised by inflammation followed by a period of immunosuppression that can last for several weeks. The immunosuppressed patients are at risk of suffering secondary or opportunistic infections, a major cause of death in intensive care units. Impairment of dendritic cells (DC), the primary initiators of T cell immunity, plays a prominent role in this immunosuppression post-SIRS. In this project we will use models of infection and trauma to characterise the mechanisms that cause DC paralysis and to develop therapies to prevent immunosuppression.
Further reading: NS Wilson et al (2006), Nat. Immunol. 7: 165-172; LJ Young et al (2007), Proc. Natl. Acad. Sci. USA 104: 17753-17758; A. Roquilly et al (2017), Immunity 47:135-147; J Vega-Ramos et al, Curr. Opin. Pharmacol. 17: 64-70.
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Villadangos Group
10 vacancies
The Villadangos group studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumour antigens to T cells by dendritic cells, B cells and macrophages. We are characterising the development, regulation and impairment of antigen presenting cells by pathogens, inflammatory mediators and tumours. We are also dissecting the biochemical machinery involved in antigen capture, processing and presentation. We use this knowledge to understand how T cell-dependent immunity is initiated and maintained, and apply it to design better vaccines and immunotherapies against infectious agents and cancer.
Villadangos Group Current Projects
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How to harness the immune system to cure cancer: adoptive cell immunotherapy
Honours
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MR1 – a molecular alarm system for intracellular bacterial infection
PhD/MPhil, Master of Biomedical Science, Honours
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Immunoregulatory functions of the MARCH family of ubiquitin ligases
Master of Biomedical Science, Honours
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How infection and trauma cause dendritic cell paralysis and lethal immunosuppression
Honours
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Immuno-paralysis following severe infections or trauma
Master of Biomedical Science, Honours
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Improving the formation of protective immunity against human viruses
PhD/MPhil, Master of Biomedical Science, Honours
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The immune signature of COVID-19 patients
PhD/MPhil, Master of Biomedical Science, Honours
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Trogocytosis: a novel communication system between cells of the immune system
PhD/MPhil, Master of Biomedical Science, Honours
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To eat, or not to eat: defining the molecular regulation of macrophage phagocytosis by SIRPα
PhD/MPhil, Master of Biomedical Science, Honours
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The immune signature of sepsis
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.