The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Immunoregulatory functions of the MARCH family of ubiquitin ligases

Villadangos Group

This project will employ biochemical techniques, microscopy, proteomics, and CRISPR-Cas9 technology to characterise the function of the MARCH family; identify novel MARCH substrates; and characterise the machinery involved in ubiquitination by MARCHs. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Jose Villadangos

Project Co-supervisor

Dr Justine Mintern

Project availability
Master of Biomedical Science
Honours

Villadangos Group

j.villadangos@unimelb.edu.au

10 vacancies

Themes
Immunology
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Discovery Research
Clinical and health systems research

The Villadangos group studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumour antigens to T cells by dendritic cells, B cells and macrophages. We are characterising the development, regulation and impairment of antigen presenting cells by pathogens, inflammatory mediators and tumours. We are also dissecting the biochemical machinery involved in antigen capture, processing and presentation. We use this knowledge to understand how T cell-dependent immunity is initiated and maintained, and apply it to design better vaccines and immunotherapies against infectious agents and cancer.