Project: Phylodynamic modelling of outbreaks of multidrug resistant enteric pathogens
Howden Group
This project will combine large bacterial datasets with epidemiological data and infectious disease modelling to develop novel approaches to better understand the drivers of these bacterial pathogens. Enteric bacterial pathogens, including Shigella species and serovars of Salmonella enterica, represent serious public health threats. The emergence of widespread multidrug resistance to standard antimicrobial therapy has resulted in changing outbreak dynamics. This computational microbiology project will work at the interface of public health microbiology. This project will integrate large bacterial genomic datasets with epidemiological data and infectious disease modelling. These approaches have been successfully used for viral outbreaks, but remain underutilised for bacterial pathogens. The application of these phylodynamic modelling will help to better understand the outbreak dynamics of enteric bacterial pathogens.
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Howden Group
5 vacancies

Our research uses genomics, molecular biology, epidemiology and clinical studies to address a broad range of issues related to invasive bacterial diseases in humans, including antimicrobial-resistant and hospital-associated pathogens such as Staphylococcus aureus, Enterococcus faecium, Klebsiella pneumoniae and Escherichia coli.
Howden Group Current Projects
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Defining how multidrug-resistant superbugs colonise the gastrointestinal tract
PhD/MPhil, Master of Biomedical Science, Honours
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Towards an understanding of last-resort antimicrobial resistance in hospital superbugs
Master of Biomedical Science, Honours
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Genomic epidemiology and AMR of Victorian Burkholderia in a global context
PhD/MPhil, Master of Biomedical Science, Honours
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Phylodynamic modelling of outbreaks of multidrug resistant enteric pathogens
PhD/MPhil, Master of Biomedical Science
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Precision genomics for antimicrobial-resistant bacterial pathogens
Master of Biomedical Science, Honours