Project: Investigating antimalarial drug resistance in response to community interventions
Day Group
Plasmodium falciparum resistance to antimalarials including chloroquine, sulphadoxine-pyrimethamine, and artemisinin-based combination therapies threatens malaria control efforts, particularly in sub-Saharan Africa where >90% of malaria-related deaths occur annually. Currently, we are monitoring the efficacy of a community-based intervention known as seasonal malaria chemoprevention, a form of targeted mass drug administration in children under 5-years, in Bongo District in the Upper East Region of Ghana in West Africa. Changes in patterns of molecular markers of antimalarial drug resistance are being monitored and analysed by genetic epidemiology methods to inform the National Malaria Control Program in Ghana, as well as to better understand the population genetics of drug resistance in the reservoir of chronic infections.
Project site: Bio21 Institute
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Day Group
8 vacancies
Professor Karen Day runs a multidisciplinary malaria research group that utilises molecular epidemiology to study the role that variation in human, parasite, and vector genomes plays in modulating transmission dynamics of Plasmodium spp. She is also interested in cell-to-cell communication in malaria parasites to alter population behaviour. She has a strong track record in interdisciplinary training of the next generation of infectious disease epidemiologists.
Day Group Current Projects
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Malaria epidemiology and elimination in high transmission settings
PhD/MPhil, Master of Biomedical Science, Honours
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Genomic epidemiology and malaria surveillance
PhD/MPhil, Master of Biomedical Science, Honours
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Investigating antimalarial drug resistance in response to community interventions
PhD/MPhil, Master of Biomedical Science, Honours
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Surveillance and spread of artemisinin drug resistance and local Anopheles spp. adaptation of Plasmodium falciparum
PhD/MPhil, Master of Biomedical Science, Honours
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Bioinformatic investigation of diversity of the variant antigen genes of Plasmodium falciparum in low and high transmission
PhD/MPhil, Master of Biomedical Science
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Insights into the evolution of variant antigen gene recombinants of Plasmodium falciparum in high transmission
PhD/MPhil
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Social networking and malaria parasite / Quorum sensing in malaria parasites
PhD/MPhil, Master of Biomedical Science
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Malaria and the human genome / Identifying regions of the human genome selected by Plasmodium spp
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.