Project: Understanding pneumococcal pathogenesis
Streptococcus pneumoniae (the pneumococcus) is the most common cause of community-acquired pneumonia and a leading killer of children world-wide. However, it is also commonly found as an asymptomatic coloniser of the upper respiratory tract (carriage). Pneumococcal carriage is an important reservoir for transmission and a precursor to disease. In this project, you will identify novel genes and characterise their role in pneumococcal carriage and/or disease. Key approaches to this project include: genetic manipulation of pneumococcal isolates, working with in vitro and/or in vivo models such respiratory cells from patients grown as air-liquid interface and mouse models, as well as microbiological and immunological analysis of local and systemic samples. Your research will provide new insights into how pneumococci colonise and cause disease.
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The Satzke group conducts research in a clinically-relevant context. We focus on the microbiology of pathogens of major global health importance (including pneumococcus and group A streptococcus) to understand their pathogenesis, interaction with viruses, and how infections can be best prevented with vaccines.
Satzke Group Current Projects
Understanding pneumococcal pathogenesis
PhD/MPhil, Master of Biomedical Science, Honours
Microbial changes following pneumococcal conjugate vaccination
Master of Biomedical Science, Honours