The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

  • Research Groups
    • Mueller Group

      Research in Scott’s group is focused on examining immune responses to both acute and chronic viral infections. A particular emphasis on T cell responses and interactions with antigen presenting cells and lymphoid tissue stromal cells is currently driving the group, as well as an interest in neuro-immune interactions.

      Other work areas include:Immunology


    Current Projects

    • T cell responses during experimental malaria infection

      T cells play key roles in protection against Plasmodium berghei infection. The mechanisms underlying T cell activation in the spleen and migration to the brain where they can cause disease are not well understood. To address this, Scott’s group have developed a novel system to image the brain in live animals undergoing malarial infection using 2-photon laser scanning microscopy. This allows temporal assessment of the immune response occurring in the brain. Using tools including TCR transgenic mice generated by the Heath group, they are examining the role of malaria-specific CD8 T cells in disease.


    Lab Team

    Mueller Group

    • Dr Yannick Alexandre
      Post-Doc
    • Research Officer
    • Keit Loi
      PhD student
    • Sarah Sandford
      PhD student
    • Thomas Hueneburg
      Masters student
    • Natasha Zamudio
      Research Officer
    • Melanie Damtsis
      Research Assistant

    Clinical Research

    Doherty Institute researchers have long standing collaborations with malaria researchers in Papua New Guinea, Malawi and Indonesia. They study the effects of malaria infection on pregnant women, their babies, and young children, including studies of new drugs to prevent malaria in Papua New Guinea and Malawi. Working with Malawian clinicians and scientists, they study immune responses in children with severe and uncomplicated malaria. The Doherty is leading a new Centre for Research Excellence in Malaria Elimination, focused on the Asia-Pacific Region. The CRE’s broad aim is to find better tools to detect, prevent and treat malaria in vulnerable groups. 

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    Current projects

    There are currently no Current projects