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Research Groups
Clinical Research
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Dunstan Group
Sarah’s group is using host and pathogen genomics to better understand infectious diseases. They perform genome-wide association studies of the host, genomic studies of the pathogen, and investigate the interaction of both genomes in tuberculosis, enteric fever and malaria patients.
Other work areas include:Enteric infections, Malaria
Current Projects
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Human and pathogen genomics of tuberculosis
To develop effective therapies for tuberculosis it is crucial to fully understand disease pathogenesis and why only some individuals are susceptible to disease. Supported by the National Health and Medical Research Council (NHMRC) and the Agency for Science, Technology and Research (A*STAR) Singapore, in collaboration with Oxford University Clinical Research Unit (OUCRU) Vietnam, Sarah’s group is investigating the interplay between the human host and Mycobacterium tuberculosis. They are employing a genomics approach to discover novel tuberculosis-associated genes in the Vietnamese, determining the contribution of bacterial genomic variability on tuberculosis outcome and drug resistance, and identifying the interaction between host and pathogen genetic variability in susceptibility to pulmonary tuberculosis. Complementary to this they are investigating the human genetic factors responsible for severe extra-pulmonary disease by performing genome-wide associations studies of tuberculosis meningitis.
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Victorian Tuberculosis Program Group
Justin’s group specialises tuberculosis (TB) with an emphasis on latent TB and conducts activities ranging from expansion of theoretical foundations for understanding latency and risk associated with TB infection to socio-cultural engagement with communities at high risk for TB, and development of strategic public health policies towards TB elimination. The group includes researchers with expertise in a range of methodologies, including clinical research, epidemiology, mathematical modelling, ethics and interventional research.
Researchers at the Doherty Institute are engaged in broad clinical research efforts related to tuberculosis (TB) disease, management and elimination. There is an active program of population health and mathematical modelling research assisting with evaluation of effective and ethical TB strategies both in Australia and internationally. In parallel, basic research on TB includes understanding the TB genome and the body’s immune response to TB. These activities are strengthened by a range of state-wide services for public health management of TB provided at the Doherty Institute including clinical care, epidemiology, contact tracing and rapid diagnosis of infection and drug resistance. The close collaboration amongst groups with complementary expertise means that the Doherty Institute is an exciting environment for developing and implementing novel, high-impact strategies towards better TB care and global elimination of this disease.
Now recruiting volunteers
There are currently no Now recruiting volunteers
Current projects
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Tuberculosis
The interaction between the host and pathogen genetics in susceptibility to tuberculosis
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Tuberculosis
The role of unconventional T cells in cancer immunity
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