Elizabeth Vincan Project A
Adult stem cells are the cell-of-origin of cancer. Stem cells are absolutely dependent on tightly controlled Wnt signalling, however, these cells initiate cancer if the Wnt pathway is abnormally switched on. Elizabeth’s research shows that the level of Wnt activity in the cancer cells is critical to cancer growth and that this level is modulated by additional signalling from the Wnt receptor complex. Using mini-gut, -liver and -stomach organoid technology developed by her collaborators, Professors Hans Clevers and Nick Barker, her group demonstrated potent anti-tumour effects by blocking Wnt receptors. This is being developed as targeted therapy for gastrointestinal cancers.
Elizabeth Vincan Project B
Some human viruses are exquisitely selective and only infect human cells. This has hampered studies to prevent and control infection. To fill this gap in knowledge, Elizabeth’s team has established patient-derived organoid models that faithfully recapitulate the key features of natural infection. Established from resected and biopsy tissue pieces, organoids contain stem cells that are coerced to generate tiny replicas that faithfully recapitulate the essential architecture and function of their tissue of origin. This enables anti-viral testing, toxicology and vaccine development using adult human tissue. We are establishing diverse human organoid models to combat emerging infections of public health importance.
Professor Elizabeth Vincan
(03) 9342 9348 | firstname.lastname@example.org
- Medical Scientist / Laboratory Head
- Viral Infectious Diseases, Bacterial and Parasitic Infections, Emerging Infections
- Discovery Research, Public Health, Clinical and health systems research
- The University of Melbourne, Department of Infectious Diseases, Victorian Infectious Diseases Reference Laboratory (VIDRL)
- Lab Group(s):
- Vincan Group
Professor Elizabeth Vincan is a Medical Scientist and Researcher at VIDRL and the Department of Infectious Diseases, Melbourne Medical School, University of Melbourne. Her role as Medical Scientist is to translate research discoveries into a clinical setting. Elizabeth is also a laboratory head at the Doherty Institute. Her team of researchers investigate how normal stem cells become cancer cells and the role Wnt signalling plays in this change. Elizabeth is an Adjunct Professor within the Curtin Medical School, Curtin University, Perth, Western Australia.